Effect of Phenotypic Selection on Stochastic Gene Expression
نویسندگان
چکیده
منابع مشابه
Effect of phenotypic selection on stochastic gene expression.
Genetically identical cells in the same population can take on phenotypically variable states, leading to differentiated responses to external signals, such as nutrients and drug-induced stress. Many models and experiments have focused on a description based on discrete phenotypic states. Here, we consider the effects of selection acting on a single trait, which we explicitly link to the variab...
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15 صفحه اولNatural selection on gene expression.
Changes in genetic regulation contribute to adaptations in natural populations and influence susceptibility to human diseases. Despite their potential phenotypic importance, the selective pressures acting on regulatory processes in general and gene expression levels in particular are largely unknown. Studies in model organisms suggest that the expression levels of most genes evolve under stabil...
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ژورنال
عنوان ژورنال: The Journal of Physical Chemistry B
سال: 2013
ISSN: 1520-6106,1520-5207
DOI: 10.1021/jp403231f